What is a symptom that indicates the combined use of alcohol and sedatives or hypnotics (tranquilizers, sleeping pills)?

★ Q: What is a symptom that indicates the combined use of alcohol and sedatives or hypnotics (tranquilizers, sleeping pills)?
  intensified euphoria
  depressed cardiac and respiratory functions
  cold bluish skin
  intensified impairment in reaction and control

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depressed cardiac and respiratory functions