What is a symptom that indicates the combined use of alcohol and narcotic pain relievers or heroin?

Question: What is a symptom that indicates the combined use of alcohol and narcotic pain relievers or heroin?
OR
What is a symptom that indicates the combined use of alcohol and narcotic pain relievers for heroin
  intensified sedation
  intensified breathing
  intensified impairment in perception
  intensified impairment in concentration

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intensified sedation